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Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder frequently accompanied by dyslipidemia. However, the relationships among Limosilactobacillus reuteri (L. reuteri) supplementation, gut microbiota-associated lipid remodeling, and PCOS-related metabolic dysfunction remain unclear. Methods: A high-fat diet combined with dehydroepiandrosterone-induced PCOS-like rat model (HFHA) was established to evaluate the effects of L. reuteri supplementation.
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