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Abstract Objective: To construct and internally validate a machine learning-assisted diagnostic model that identifies gastroesophageal varices (GEV) in patients with cirrhosis from routinely collected clinical and laboratory data. Methods: We retrospectively analyzed 5,037 patients with cirrhosis who underwent endoscopy from January 2024 through May 2026. Random allocation at a 7:3 ratio produced a training set (n = 3,526) and a validation set (n = 1,511).
1 Introduction Imatinib (IMB, also known by its trade name of Gleevec/Glivec), is a type of chemotherapy medication approved by the Food and Drug Administration (FDA) in 2001 (Diculescu et al., 2009). As a pioneer tyrosine kinase inhibitor (TKI), it is applied to treat certain types of cancers such as chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), for patients in which the Philadelphia chromosome is positive (Ph+) (Qu et al., 2019).
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