ORIGINAL ARTICLE Xuehui Zeng and Qingqi Zheng contributed equally to this article. Abstract Background Sevoflurane (Sev) is a commonly used volatile anesthetic that might suppress the process of breast cancer. Also, circular RNAs (circRNAs) have been reported to partake in the pathogenesis of breast cancer. Accordingly, this research was designed to investigate the mechanism of hsa_circ_0005962 on Sev-mediated breast cancer development. Methods Sev was applied to treat breast cancer cells.