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Xuezhu Zhang

As seen in: Frontiers, Chemistry World
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Articles by Xuezhu Zhang

Ferroptosis-associated signaling pathways and therapeutic approaches in depression

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By Xuezhu Zhang
| Frontiers
Xuyang FengWenyu ZhangXiaoxi LiuQiuxuan WangXiao DangJingxian HanXuezhu Zhang1,2* 1,2 1,2,3 1,2,3 1,2 1,2,3† 1,2,3† First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China Tianjin University of Traditional Chinese Medicine, Tianjin, China Ferroptosis, a newly identified form of cell death, is characterized by excessive iron accumulation and lipid peroxidation.
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Modulating the Cellular Microenvironment with Disulfide-Containing Nanoparticles as an Auxiliary Cancer Treatment Strategy

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By Jingmei Yang, Yong-Chao Duan, Xuezhu Zhang
| Chemistry World Verified
Stimuli-responsive drug release nanoparticles are of particular interest due to their enhanced effects and reduced systemic toxicities in the area of cancer therapeutics. The effect of these nanoparticles on the cellular microenvironment has not yet been clearly defined. In this context, redox-responsive nanoparticles were synthesized with disulfide-containing linkages. These nanoparticles depleted cellular GSH level and modulated the cellular redox microenvironment to more oxidizing conditions.
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