Abstract Cervical cancer is the 4th most common malignancy in women. Radiotherapy (RT) plays an essential role in cervical cancer treatments, and this study reports the role of REV7 in cervical cancer RT. Results showed that loss of REV7 contributed to increased the radiosensitivity of cervical cancer both in vitro and in vivo. Further molecular biology experiments demonstrated REV7-silence enhanced apoptosis, aggravated radiation-induced ROS, and accelerated ferroptosis after RT.
