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Bone is a dynamic organ with remarkable regenerative properties. However, bone homeostasis requires viable cells (osteoblasts, osteoclasts, and osteocytes), adequate vascularity, stability, the presence of growth factors and a matrix for growth. Unfortunately, there are often situations where one or more of these conditions are inadequate, and as surgeons we have to provide assistance to allow bone to heal.
AbstractThe continual cycle of bone formation and resorption is carried out by osteoblasts, osteocytes, and osteoclasts under the direction of the bone-signaling pathway. In certain situations the host cycle of bone repair is insufficient and requires the assistance of bone grafts and their substitutes. The fundamental properties of a bone graft are osteoconduction, osteoinduction, osteogenesis, and structural support.
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