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Palmoplantar pustulosis (PPP) is a refractory, nonbacterial impetigo confined to the palms and soles. Its pathogenesis is still obscure, but it may be associated with the large eccrine sweat glands and pores of palmoplantar skin. PPP is considered to be a localized pustular psoriasis. Interleukin (IL)‐8, IL‐36γ and IL‐36Ra play important roles in the pathogenesis of pustular psoriasis, but their role in PPP is unclear.
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