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Y. Zen

As seen in: Nature
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Articles by Y. Zen

Nrf2-mediated metabolic reprogramming drives regulatory T cell accumulation in hepatocellular carcinoma

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By M. J. Fleming, Q. Peng, V. Sharma, C. L. Zhang, A. Kurt, X. Liao, Z. Q. Liu, R. Miquel, D. Sarker, J. G. Leslie, A. Sanchez-Fueyo, E. Perpiñán, N. Sompairac, D. Marin Correa, E. Ramon-Gil, RCH Man, D. Camell-Raventos, R. Savoldelli, L. Bellersheim, CX Santos, M. Elgosbi, JJ Lozano, M. Maddaloni, C. Schmidl, E. Kodela, M. Piqué-Gili, R. Pinyol, S. Higginbotham, E. Landman, J. Torres-Yaguana, T. Dowe, M. Habarwaa, Y. Zen, S. Kordasti, T. Tree, AM Shah, GO Fruhwirth, AT Dinkova-Kostova, EL Pearce, JM Llovet, N. Safinia
| Nature Verified
Abstract Excessive recruitment and/or activation of regulatory T cells (Treg) into the tumour microenvironment (TME) hamper anti-cancer immunity. Targeting Tregs is therefore a promising strategy to reverse the immunosuppressive features of the TME. Here, we investigate how the development of hepatocellular carcinoma (HCC) impacts the molecular programmes of tissue-resident Tregs. Tregs residing in non-tumoral liver are metabolically inert and prone to apoptosis.
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