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Roberts TC, Langer R, Wood MJA (2020) Advances in oligonucleotide drug delivery. Nat Rev Drug Discov 19(10):673–694. https://doi.org/10.1038/s41573-020-0075-7 Article PubMed PubMed Central CAS Google Scholar Kulkarni JA, Witzigmann D, Thomson SB, Chen S, Leavitt BR, Cullis PR et al (2021) The current landscape of nucleic acid therapeutics. Nat Nanotechnol 16(6):630–643.
PREBIOTIC CHEMISTRY Nature Chemistry volume 13, pages 725–726 (2021)Cite this article 439 Accesses 1 Altmetric Metrics details Subjects The origin and evolution of translational machinery — which produces a specific peptide from an RNA sequence — is a major unsolved puzzle in prebiotic chemistry. Now, the coupling of amino acids directed by RNA templates in the absence of a ribosome provides clues on how this protein synthesis process might have started.
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