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Yağız Savcı

As seen in: Nature, Royal Society of Chemistry
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Articles by Yağız Savcı

Tissue composition shapes differential skeletal integration strategies during axolotl limb regeneration

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By Rita Aires, Sean Keeley, Mario Carreira, Yağız Savcı, Ulrike Friedrich, Andreas Dahl, Can Aztekin, Tatiana Sandoval-Guzmán, Kerstin Brandt, Doğa Berşan Güneş, Pedro Capucho
| Nature Verified
Abstract Limb regeneration requires rebuilding the missing structures and integrating them with stump tissues. Osteoclast-mediated tissue resorption is essential for skeletal integration during regeneration. However, it is unknown if skeletal tissue composition impacts its resorption and, if so, how it is regulated. Here, we show that osteoclast-mediated skeletal resorption is activated in amputations damaging the diaphysis, but not the epiphysis, of skeletal elements.
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Grapefruit Derived Extracellular Vesicles as a Promising Cell-free Therapeutic Tool for Wound Healing

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By Yağız Savcı, Batuhan Turhan Bozkurt, Ezgi Avşar Abdik, Pakize Neslihan Taşlı
| Royal Society of Chemistry Verified
Grapefruit Derived Extracellular Vesicles as a Promising Cell-free Therapeutic Tool for Wound Healing Due to the prevalence of individuals suffering from chronic wounds, developing safe and effective wound care agents is one of the more prominent fields of research in biology. However, wound healing is a complex, multi-stage biological process, involving multiple a sequence of biological responses from different types of cells, secreted mediators, and extracellular matrix elements.
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