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Abstract Dysregulated splicing factors play critical roles in tumor progression. Here, we identify family with sequence similarity 50 member A (FAM50A) as a pivotal oncogenic splicing factor involved in esophageal squamous cell carcinoma (ESCC). Multi-omics and multi-cohort analyses revealed that FAM50A is upregulated in ESCC and correlates with a poor prognosis.
1 Introduction Botulinum toxin type A (BTX-A) injections rank among the most commonly performed cosmetic procedures worldwide. The pharmacological effect of intramuscular BTX-A is mediated through its binding to receptor sites at motor nerve terminals, resulting in partial chemical denervation of the targeted muscle [1].
Aim. Midwives are prone to suboptimal health status (SHS), while there is a lack of unified measurement standard of SHS for them to early detect and prevent SHS. This study aimed to evaluate validity and reliability of Subhealth Measurement Scale V1.0 (SHMS V1.0) in midwives. Design and Methods. The cross-sectional study had 842 midwives from 46 midwifery institutions in southeastern China completing the SHMS V1.0 with 39 items.
Resveratrol drives cancer cell senescence via enhancing p38MAPK and DLC1 expression Pro-senescence therapy is a recently proposed anti-cancer strategy and has been shown to effectively inhibit cancer. Resveratrol is gaining attention for its cancer preventive and suppressive properties. The mechanisms of resveratrol on cancer suppression by inducing cancer cell senescence are unclear.
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