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AbstractBinding of chemokines to their cognate receptors on monocytes instigates a cascade of events that directs these cells to migrate to sites of inflammation and cancerous tissues. Although targeting of selected chemokine receptors on monocytes exhibited preclinical efficacy, attempts to translate these studies to the clinic have failed thus far, possibly due to redundancy of the target receptor.
Identification of Motile Sperm Domain–Containing Protein 2 as Regulator of Human Monocyte Migration Itzhak Mendel, Niva Yacov, Yaniv Salem, Oshrat Propheta-Meiran, Eti Ishai, Eyal Breitbart The Journal of Immunology January 30, 2017, 1601662; DOI: 10.4049/jimmunol.1601662
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