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Abstract Background: Drug-induced liver injury (DILI) is an important cause of acute liver failure, and antimicrobial agents are among its most frequent causes. However, the association of clinically apparent liver injury with piperacillin-tazobactam is uncommon. Case presentation: A 73-year-old man with normal liver biochemistry at admission received empirical piperacillin-tazobactam for suspected pulmonary and central nervous system infection.
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