Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. Supporting Information Filename Description cbdd70258-sup-0001-FigureS1.docWord document, 728 KB Figure S1: Western blotting analysis of Vismodegib-mediated modulation of the Hedgehog signaling pathway in lung tissues of COPD mice. n = 8, ***p < 0.001, and ****p < 0.0001.