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Abstract Myasthenia gravis (MG) is an autoimmune disorder characterized by B cell dysfunction. Here, we designed B cell maturation antigen (BCMA)/CD19 chimeric antigen receptor T cell (CAR T cell) therapy for six refractory MGs, demonstrating favorable safety with grade 1 cytokine release syndrome observed. CAR T cell expansion induced profound B cell depletion, a sustained reduction in acetylcholine receptor (AChR) antibody titers, and symptom improvement.
Abstract Parallel and energy-efficient searching of the shortest paths on a large graph is challenging. Conventional methods commonly used are sequential and computing intensive, rendering them inadequate for addressing large-scale and real-time situations. Here, we propose a highly parallel, computation- and energy-efficient approach to shortest path–based graph learning based on an emerging memristor spiking neural network via algorithm-device codesign.
Discussion This protocol describes a randomised, sham-controlled, parallel-group, single-centre trial with a separation of the participant, practitioner, assessor and statistician. We aim to investigate the efficacy and safety of TEAS for PD compared with a TEAS-sham group by validated evaluation tools. Treatment timing plays a pivotal role in PD management.
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