CONFLICTS OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description ardp202400302-sup-0001-SupplMat_InChI_Activity.doc91.5 KB Supporting information. ardp202400302-sup-0002-Necroptosis_inhibitor_Supporting_information20240423.docx62.8 MB Supporting information. REFERENCES 1, , , Autoimmun. Rev. 2021, 20, 102743. 2, , , , , , , , , , , , , , , , , , , , J. Autoimmun. 2019, 103, 102299. 3, , , , , , , , Arthritis Rheum. 2022, 74, 2032.