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1 Introduction High-performance insulation materials that exhibit a superior combination of mechanical strength and thermal stability are critically needed for extreme environments such as aerospace applications [1-5]. Historically, silica aerogels have been prime candidates due to their ultralow density, excellent high-temperature resistance, and outstanding thermal insulation properties [6-8].
Abstract Respiratory syncytial virus (RSV) hijacks cholesterol or autophagy pathways to facilitate optimal replication. However, our understanding of the associated molecular mechanisms remains limited. Here, we show that RSV infection blocks cholesterol transport from lysosomes to the endoplasmic reticulum by downregulating the activity of lysosomal acid lipase, activates the SREBP2–LDLR axis, and promotes uptake and accumulation of exogenous cholesterol in lysosomes.
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