1 Background Gliomas are the most common primary intracranial tumors that originate from brain glial cells (1). The grading system and classification criteria for brain gliomas are based on their histological features, cellular heterogeneity, and biological behavior. The 2021 WHO classification has taken a significant step in advancing the role of molecular diagnostics by incorporating critical diagnostic genes, molecules, pathways, and/or combinations into tumor classification (2).
