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Abstract To evaluate the effects of prophylactic hydrocortisone (pHCT) on the odds of death or moderate to severe bronchopulmonary dysplasia (BPD) in preterm neonates. Multi-center retrospective cohort study of infants born <28 weeks in the Canadian Neonatal Network 2019–2023 who received pHCT with 1:1 propensity score-matched controls. Hierarchical composite endpoints were explored using win odds analyses. There were 361 infants per group with balanced baseline characteristics.
Abstract The single-pass transmembrane receptor guanylyl cyclase A (GC-A), also known as natriuretic peptide receptor A (NPR-A) or NPR1, regulates blood pressure through vasodilation and natriuresis, making it a promising therapeutic target for hypertension and heart failure. We describe two monoclonal antibodies, XX16 and REGN5308, that differentially activate GC-A.
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