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1 Introduction Resistant hypertension (RH) is defined as blood pressure (BP) remaining above target despite an optimized three-drug antihypertensive regimen that includes a diuretic, or as BP controlled only with the use of four or more antihypertensive agents [1]. In a large meta-analysis, the estimated prevalence of true RH was approximately 10.3% among treated hypertensive patients, highlighting its substantial clinical burden [2].
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