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Antimicrobial resistance is a global public health crisis, with multidrug-resistant P. aeruginosa among the most critical threats. The high cost and slow pace of novel antibiotic development, coupled with rapid resistance evolution, demand innovative strategies. Here, we present a Trojan horse approach using siderophore-antibiotic conjugates (SACs) to hijack bacterial iron uptake systems and deliver β-lactam payloads across the Gram-negative outer membrane.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
