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Yicai Cheng

As seen in: Nature, Pakistan Journal of Medical Sciences
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Articles by Yicai Cheng

FATP5 loss in hepatocellular carcinoma cells orchestrates tumor-promoting microenvironment by inducing passive long-chain fatty acid accumulation within tumor-associated endothelial cells

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By Zhengwei Zhao, Xiaoyan He, Zuotian Huang, Teng Wei, Kelin Wu, Geyan Wu, Yuan Feng, Jincui Yang, Xinrong He, Shuhui Xu, Xuelong Zheng, Xiaoqiang Chen, Kaiyue Yao, Wenyi Yin, Yicai Cheng, Xiaoyi Zhan, Xiaoli Pan, Yueyang Hu, Stephanie Roessler, Yunting Jian, Junyao Xu, Qiangnu Zhang, Chuli Fu, Wenyun Fu, Yuexiang Ouyang, Jiang Qing-Ping, Guang-Rong Yan
| Nature Verified
Abstract Hepatocellular carcinoma (HCC) is characterized by severe immunosuppression and metabolic reprogramming, yet the spatial dynamics of lipid flux between malignant and stromal cells remain poorly understood. Here, we identify a profound, type-specific metabolic rewiring in HCC driven by the widespread downregulation of fatty acid transport protein 5 (FATP5).
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