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Abstract Preemptive pharmacogenetics (PGx) testing, which leverages genetic variation to predict drug response and toxicity, represents a pivotal advancement in precision medicine. By predicting drug-gene interactions and guiding precision dosing, it demonstrates significant potential to enhance drug safety and efficacy. However, its integration into routine clinical practice still faces a substantial translational gap.
Clinical Trial Brief Report Hui Zhang, Pengfei Wang, Zhuoyan Li, Yingyi He, Wenting Gan and Hua Jiang DOI: 10.1158/1078-0432.CCR-20-4543 Abstract Purpose: The survival rate of children with refractory/relapsed acute myeloid leukemia (R/R-AML) by salvage chemotherapy is minimal. Treatment with chimeric antigen receptor T cells (CAR-T) has emerged as a novel therapy to improve malignancies treatment.
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