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Yingying Zhen

As seen in: Nature, MDPI
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Articles by Yingying Zhen

Preclinical characterization and first-in-human phase I dose-escalation results with JYB1907, a novel anti-GARP-TGF-β1 complex monoclonal antibody in patients with advanced solid tumors

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By Peiwen Ma, Rongyang Xu, Lei Yang, Yingying Zhen, Xiaodan Cao, Lu Zhang, Yongchang Zhang, Funan Liu, Shuhang Wang, Ning Li
| Nature Verified
Abstract Transforming growth factor-β1 (TGF-β1) promotes immunosuppression in the tumor microenvironment via the GARP-latent TGF-β1 complex on regulatory T cells. JYB1907 is a humanized IgG4 monoclonal antibody targeting this complex. Preclinically, JYB1907 bound GARP-latent TGF-β1 complex with high affinity and specificity, inhibited the release of TGF-β1, and showed monotherapy antitumor activity and enhanced anti-PD-1 combination activity in humanized mouse models.
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Household Carbon Footprint Characteristics and Driving Factors: A Global Comparison Based on a Dynamic Input–Output Model

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By Xi Chen, Yingying Zhen, Zhanming Chen
| MDPI
Abstract : Carbon emissions are rapidly increasing with continuing global economic development, necessitating an urgent energy revolution. Often, when calculating carbon footprint, analysts have failed to account for changes in capital stock and the impact of indirect emissions caused by the consumption of imported products. Furthermore, the homogenization of industrial and resident sectors has reduced our understanding of the specific driving forces behind carbon emissions.
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