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Abstract Introduction: The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway constitute the core proteolytic metabolic networks that maintain cellular protein homeostasis (proteostasis) and organelle metabolic identity. Intracellular pathogens frequently reprogram host metabolic pathways to establish replicative niches, yet how they manipulate proteostatic metabolism to remodel organelle maturation remains incompletely understood.
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