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A total of 400 patients were included (Supplementary Figure S1). The indications for a kidney biopsy throughout the retrospective study period of 1988–2015 followed the current standard of care throughout this period. The clinicians could report several indications for each case, and the two most common were hematuria (n = 316) and proteinuria (n = 266). Most patients (72%) were male, typical for Norwegian IgAN cohorts [5, 21].
This retrospective cohort study adhered to the guiding principles of the Declaration of Helsinki and was approved by the Regional Ethics Committee of Western Norway (No. 15145). Informed consent was obtained from all participants. We identified adults with primary IgAN diagnosed from May 1988 to 2012 who had progressed to ESKD. Overall, 143 patients were included (Fig. 1).
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