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Abstract Neuropathic pain (NP) remains refractory to conventional therapy partly because its pathogenesis is incompletely understood. G protein-coupled receptor 177 (GPR177), a multi-pass transmembrane protein, regulates Wnt trafficking and secretion. Here, we use a chronic constriction injury model in male rats and find GPR177 predominantly expresses in spinal astrocytes and co-localizes with complement component 3 (C3).
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
