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Abstract Background: Emerging evidence suggests that oral microbial dysbiosis contributes to neuropsychiatric disorders through microbiome–immune interactions. We previously identified an oral-origin Streptococcus salivarius enriched in individuals with schizophrenia (SCZ) and demonstrated its ability to become enriched in the intestine after oral administration. However, whether this disease-associated bacterium remodels host adaptive immunity remains unclear.
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