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Abstract Cleft lip and palate (CLP) are common congenital craniofacial anomalies, but the post-transcriptional mechanisms regulating palatal shelf growth remain incompletely understood. In this study, small RNA sequencing was used to profile miRNA expression during murine palatal shelf development, and miR-124-3p was selected for functional assessment. In situ hybridization detected miR-124-3p in palatal tissues at multiple embryonic stages.
Abstract This study is the first to investigate the process of osteoclast (OCL) differentiation, its potential functions, and the associated mRNA and signalling pathways in embryonic palatal bone. Our findings suggest that OCLs are involved in bone remodelling, bone marrow cavity formation, and blood vessel formation in embryonic palatal bone.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
