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Articles by Young Su
Preventive administration of Bifidobacterium animalis subsp. lactis HEM20–01 attenuates the development of atopic dermatitis-like inflammation in mice, along with gut microbial and succinate alterations
Abstract Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder frequently accompanied by gut dysbiosis and neurobehavioral comorbidities, but the microbial metabolites mediating gut–skin crosstalk remain unclear. We investigated whether preventive administration of Bifidobacterium animalis subsp. lactis HEM20–01 attenuates the development of AD-like phenotypes and characterized the accompanying gut microbiome, succinate, intestinal, and behavioral alterations.
Miniaturizing and modifying natural proteins with Raygun
Abstract Proteins have evolved over billions of years through coordinated substitutions, insertions and deletions, yet computational protein design cannot fully replicate nature’s ability to engineer new proteins from existing templates. Protein language models1,2,3 generate informative per-residue representations, but harnessing them for large-scale, function-preserving sequence modifications has remained beyond reach.
Additive Renoprotective Effects of Oral Calcitriol on patients with IgA Nephropathy Receiving RAS Blockade
Patients with immunoglobulin A nephropathy (IgAN) and moderate proteinuria are at risk of progressive renal failure despite the maximal use of renin-angiotensin system blockade (RASB). This study evaluated the efficacy of active vitamin D in reducing proteinuria in patients with IgAN receiving RASB. In this double-blind, placebo-controlled trial, we enrolled biopsy-confirmed patients with IgAN and persistent proteinuria (0.5 g/d–3.5 g/d) after maximal use of RASB.
Additive renoprotective effects of oral calcitriol on patients with IgA nephropathy receiving RAS blockers
Patients with immunoglobulin A nephropathy (IgAN) and moderate proteinuria are at risk of progressive renal failure despite the maximal use of renin–angiotensin system blockers (RASBs).
Smoking cessation and atherosclerotic cardiovascular events and mortality in chronic kidney disease
Smoking cessation is recommended to reduce excess atherosclerotic cardiovascular disease (ASCVD) and mortality in patients with chronic kidney disease (CKD). However, this recommendation is largely based on observational studies on the general population Therefore, we aimed to evaluate the association of smoking dose and smoking cessation duration with ASCVD and mortality in patients with CKD.
Exploring Molecular Genetic Alterations and RAF Fusions in Melanoma: A Belvarafenib Expanded Access Program in Patients with RAS/RAF-Mutant Melanoma
The incidence of newly diagnosed patients with melanoma has risen each year, with 324,635 new cases and 57,043 new deaths in 2020.1 Melanoma incidence is also on the rise in East Asia, yet a comprehensive understanding of the molecular landscape is lacking in this population.2 Over the past decade, systemic therapies for malignant melanoma have evolved, with standard options including immune checkpoint inhibitors and molecularly targeted therapies for advanced-stage disease with regional or...
Proteinuria, measured or estimated albuminuria for risk prediction in patients with chronic kidney disease?
Although albuminuria is the gold standard for defining chronic kidney disease (CKD), total proteinuria has also been widely used in real-world clinical practice. Moreover, the superiority of the prognostic performance of albuminuria over proteinuria in patients with CKD remains inconclusive. Therefore, we aimed to compare the predictive performances of albuminuria and proteinuria in these patients.
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