Introduction Colorectal cancer (CRC) is one of the deadliest malignancies affecting both men and women worldwide; it is the third most commonly diagnosed cancer and the second most common cause of cancer-related deaths.1 Previous studies have implicated chromosome and microsatellite instability, CpG island methylator phenotypes, and epigenetic alterations in CRC tumorigenesis and metastasis.2–4 Studies have also reported distinct molecular features and varying gut microbiota in CRC...
