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Abstract Non-functioning gonadotroph (NFG) tumors are the most common type of non-functioning pituitary adenomas and cause significant morbidity through mass effect. The molecular programs that distinguish NFG tumor cells from normal gonadotrophs and underlie tumor growth remain poorly understood.
Maternally expressed gene 3 (MEG3) is an imprinted gene belonging to the imprinted DLK1–MEG3 locus located at chromosome 14q32.3 in humans. Its mouse ortholog, Meg3, also known as gene trap locus 2 (Gtl2), is located at distal chromosome 12. The MEG3 gene encodes a long noncoding RNA (lncRNA) and is expressed in many normal tissues. MEG3 gene expression is lost in an expanding list of primary human tumors and tumor cell lines.
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