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Yunzhong Nie

As seen in: Cell Metabolism, Texas Medical Center
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Articles by Yunzhong Nie

Microbial aldehyde-alcohol dehydrogenase degrades metformin to limit therapeutic response in type 2 diabetes

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By Yue Zhao, Chen Peng, Ying Xia, Tiejun Dong, Xiaodong Shan, Xiang Li Zhong, Jingchuan Xue, Ziqian Bing, Pengfei Li, Jingyu Han, Yunzhong Nie, Kelei He, Yu Cao, Tingting Wang
| Cell Metabolism Verified
Results Metformin bypasses hepatic metabolism and is renally excreted intact, making gastrointestinal uptake central to systemic exposure.
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Integration of Kupffer Cells Into Human iPSC-Derived Liver Organoids for Modeling Liver Dysfunction in Sepsis

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By Yunzhong Nie
| Texas Medical Center
Abstract Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells.
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