Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Abstract In the state of obesity, miR-548ab targets and downregulates SLC25A21, leading to reduced GLUT4 expression. However, the precise mechanism by which SLC25A21 regulates GLUT4 expression remains unclear. This study aims to investigate whether downregulation of SLC25A21 reduces GLUT4 expression by increasing reactive oxygen species (ROS) levels and inhibiting the PI3K/AKT/KLF15 signaling pathway, thereby contributing to impaired glucose metabolism.
Abstract The molecular underpinnings of obesity-induced insulin resistance, a key driver of type 2 diabetes mellitus (T2DM), remain incompletely understood, limiting targeted therapies. While our prior work revealed that miR‑548ab impairs glucose homeostasis by downregulating GULP1, the precise mechanism by which GULP1 regulates insulin sensitivity, particularly through the GLUT4 trafficking machinery, is unknown.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
