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To the Editor We read with great interest two recent studies by Handa et al. [1] and Bartalucci et al. [2] reporting novel chromosomal deletions within the 3’ untranslated region (UTR) of HMGA2 (Δ3’HMGA2) in myeloproliferative neoplasms (MPNs). Both teams identified submicroscopic deletions ranging from 1.3 kb to 2.7 Mb that encompass the MIRLET7 microRNA tumor suppressor response element.
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