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This study was designed to investigate the protective effect of curcumin against D-galactose (D-gal)-induced premature ovarian failure (POF) in mice. A mouse POF model was induced by subcutaneous injection of D-gal (200 mg.kg-1.d-1) daily for 42 days. Mice in the curcumin group received both D-gal treatment and intraperitoneal injection of curcumin (100 mg.kg-1.d-1) for 42 days. Ovarian function, oxidative stress and apoptosis were evaluated.
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