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Abstract Background: Oral human papillomavirus (HPV) infection precedes most HPV-related oropharyngeal cancers, but determinants of oral HPV prevalence and incidence in people living with HIV (PLWH) and populations at increased risk of HIV acquisition remain unclear. Methods: PubMed, Embase, and the Cochrane Library were searched through July 10, 2026, for observational studies of laboratory-confirmed oral HPV prevalence, incidence, or clearance in adults with or at risk for HIV.
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