Braz. J. Med. Biol. Res.2026;59:e15117. Open Access Peer-Reviewed Research Articles DOI: 10.1590/1414-431X2025e15117 Acute lung injury (ALI) is a common complication of sepsis in connection with excessive inflammation and accumulation of oxidative stress. Sorting nexin 10 (SNX10) is a sorting nexin family member involved in inflammatory processes. This study aimed to explore the function of SNX10 in ALI. The cecal ligation and puncture (CLP) model was established to induce ALI in C57BL/6J mice.