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The authors have declared no competing interest. This study was mainly funded by the Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 with reference number 2023C04049 and Ningbo International Collaboration Program 2023 with reference number 2023H025. This work was also supported by the European Union's Horizon 2020 research and innovation programme under grant agreement No 633491 (DOLORisk).
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