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Signal regulatory protein α (SIRPα) plays an important part to restrain macrophage chemotaxis, secretion and phagocytosis. However, the signals involved in SIRPα-mediated control of macrophage inflammatory responses are poorly defined. Here we report that the inhibitory effect of SIRPα is mainly due to its suppression on macrophage aerobic glycolysis (Warburg effect).
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.