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Zhanfang Guo

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Articles by Zhanfang Guo

HER2; p53 co-mutated cancers show increased histone acetylation and are sensitive to neratinib plus trastuzumab deruxtecan

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By Xiaoqing Cheng, Jacob Hsia, Jesus Iraheta, Joanna Gongora, Maureen K. Highkin, Xiaohua Jin, Julie L. Prior, John Edwards, Shunqiang Li, Ian Hagemann, Cynthia X Ma, Zongtao Lin, Benjamin Garcia, Ron Bose, Zhanfang Guo
| Nature Verified
Abstract In metastatic breast cancer, HER2-activating mutations often co-occur with TP53 mutations, a combination linked to poor response to neratinib and worse prognosis. To model this clinical challenge, we bred HER2V777L transgenic mice with two TP53 mutant alleles: TP53R172H (the murine homolog of human TP53 R175H) and TP53fl/fl, which mimics p53 truncations common in human tumors. TP53 mutations accelerated tumor development and reduced survival in HER2-mutant mice.
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