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Articles by Zhen Bian
Soil and Water Conservation Vegetation Restoration in Alpine Areas-Taking a Hydropower Station as an Example
1. Introduction After the 18th CPC National Congress, General Secretary Xi Jinping has incorporated the construction of an ecological civilization into the “five-in-one” overall layout of the socialist cause with Chinese characteristics. In the course of this, he put forward the development concept of ‘green mountains are golden mountains’.
Interaction Mechanism between Inter-Organizational Relationship Cognition and Engineering Project Value Added from the Perspective of Dynamic Impact
1. Introduction As the external environment becomes increasingly dynamic and complex and the pace of technological updates accelerates, the traditional criteria for project success, which focus on achieving the three main goals of ‘cost, time and quality’, no longer align with the patterns of societal development [1]. Many experts agree that value delivery has now become the standard for measuring the success of engineering projects [2,3,4].
Protocol for development and validation of a prediction model for post-induction hypotension in elderly patients undergoing non-cardiac surgery: a prospective cohort study
Protocol for development and validation of a prediction model for post-induction hypotension in elderly patients undergoing non-cardiac surgery: a prospective cohort study Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
SIRPα sequesters SHP-2 to promote IL-4 and IL-13 signaling and the alternative activation of macrophages
Lei Shi https://orcid.org/0000-0002-6631-6732, Koby Kidder, Zhen Bian, Samantha Kuon Ting Chiang https://orcid.org/0000-0001-6770-0536, Corbett Ouellette https://orcid.org/0000-0002-6862-0252, and Yuan Liu https://orcid.org/0000-0003-0535-0600 Aiding alternative activation Abstract Supplementary Material REFERENCES AND NOTES Aiding alternative activation The cytokines interleukin-4 (IL-4) and IL-13 act through receptors that share a common subunit to generate alternatively activated...
Non-Lyn Src Family Kinases Activate SIRPα-SHP-1 to Inhibit PI3K-Akt2 and Dampen Proinflammatory Macrophage Polarization
Lei Shi, Zhen Bian, Koby Kidder, Hongwei Liang and Yuan Liu J Immunol September 1, 2021, 207 (5) 1419-1427; DOI: https://doi.org/10.4049/jimmunol.2100266 Key Points SIRPα controls TLR agonist– and IFN-γ–induced macrophage proinflammatory activation. SIRPα deficiency exacerbates type I diabetes and peritonitis in mice. SFK(s), but not Lyn, phosphorylate SIRPα to recruit SHP-1 in proinflammatory states.
Non-Lyn Src Family Kinases Activate SIRPα-SHP-1 to Inhibit PI3K-Akt2 and Dampen Proinflammatory Macrophage Polarization
Lei Shi, Zhen Bian, Koby Kidder, Hongwei Liang and Yuan Liu J Immunol August 4, 2021, ji2100266; DOI: https://doi.org/10.4049/jimmunol.2100266 Key Points SIRPα controls TLR agonist– and IFN-γ–induced macrophage proinflammatory activation. SIRPα deficiency exacerbates type I diabetes and peritonitis in mice. SFK(s), but not Lyn, phosphorylate SIRPα to recruit SHP-1 in proinflammatory states. Abstract Macrophage functional plasticity plays a central role in responding to proinflammatory stimuli.
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
Abstract Radiotherapy (RT)-induced tumoricidal immunity is severely limited when tumors are well-established. Here, we report that depleting SIRPα on intratumoral macrophages augments efficacy of RT to eliminate otherwise large, treatment-resistant colorectal (MC38) and pancreatic (Pan02 and KPC) tumors, inducing complete abscopal remission and long-lasting humoral and cellular immunity that prevent recurrence.
Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ
Koby Kidder, Zhen Bian, Lei Shi and Yuan Liu J Immunol November 15, 2020, 205 (10) 2821-2833; DOI: https://doi.org/10.4049/jimmunol.2000652 Key Points SIRPα deficiency enables various inflammatory stimuli to confer sHLH/CSS in mice. Macrophage depletion, but not IFN-γ neutralization, precludes sHLH in SIRPα−/− mice. SIRPα negatively regulates TLR9 signaling by inhibiting Erk1/2 and p38 activation.
Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ
Koby Kidder, Zhen Bian, Lei Shi and Yuan Liu J Immunol October 7, 2020, ji2000652; DOI: https://doi.org/10.4049/jimmunol.2000652 Key Points SIRPα deficiency enables various inflammatory stimuli to confer sHLH/CSS in mice. Macrophage depletion, but not IFN-γ neutralization, precludes sHLH in SIRPα−/− mice. SIRPα negatively regulates TLR9 signaling by inhibiting Erk1/2 and p38 activation.
Arginase‐1 is neither constitutively expressed in nor required for myeloid‐derived suppressor cell‐mediated inhibition of T‐cell proliferation
Although previous reports suggest that tumor‐induced myeloid‐derived suppressor cells (MDSC) inhibit T cells by L‐arginine depletion through arginase‐1 activity, we herein show that arginase‐1 is neither inherently expressed in MDSC nor required for MDSC‐mediated inhibition.
LPS-primed CD11b<sup>+</sup> leukocytes serve as an effective carrier of Shiga toxin 2 to cause hemolytic uremic syndrome in mice
LPS-primed Stx2-induced HUS (LPS-Stx2 HUS) in mice28 was established for the study. C57BL/6 mice (6–10 weeks old, 18–22?g) purchased from the Jackson Laboratory were housed in a pathogen-free animal facility. All experiments using animals and procedures of animal care and handling were carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of NIH.
Tumor conditions induce bone marrow expansion of granulocytic, but not monocytic, immunosuppressive leukocytes with increased CXCR2 expression in mice - Bian - 2018 - European Journal of Immunology - Wiley Online Library
Myeloid‐derived suppressor cells (MDSCs) promote tumor growth through, in part, inhibiting T‐cell immunity. However, mechanisms underlying MDSC expansion and guidance of MDSCs toward the tumor microenvironment remain unclear. Employing Percoll density gradients, we separate bone marrow (BM) leukocytes from tumor‐bearing mice into four density‐increasing bands with myeloid leukocytes enriched in bands III and IV.
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice
Chronic diseases are often associated with altered inflammatory response, leading to increased host vulnerability to new inflammatory challenges. Employing streptozotocin (STZ)-induced diabetes as a model, we further investigate mechanisms leading to enhanced neutrophil (polymorphonuclear leukocytes [PMN]) responses under hyperglycemia and compare them with those under chronic colitis.
Pyruvate kinase type M2 promotes tumor cell exocytosis via phosphorylating synaptosome-associated protein-23
Tumor cells secret large amount of microvesicles (MVs) which are involved in remodeling tumor-stromal interactions to promote malignancy. The regulatory mechanisms governing the active exocytosis in tumor cells, however, remain incompletely understood. We show here that tumor cell exocytosis is tightly controlled by aerobic glycolysis (Warburg effect) and pyruvate kinase type M2 (PKM2), which is commonly upregulated and phosphorylated in tumor cells, plays critical roles in promoting exocytosis.
Reprogramming of myeloid compartments supporting tissue repair during DSS-induced colitis recovery
Myeloid-derived suppressor cells (MDSC) emerging during tumor growth or chronic inflammation play a critical role in regulating T cell function. However, mechanisms governing the generation of these cells remain unclear and need to be further defined. Using a DSS-induced colitis and recovery model, we characterized the dynamic changes within the myeloid compartments and the emerging of MDSC during active and resolution phases of inflammation.
Signal regulatory protein α suppresses macrophage inflammatory responses via reducing PKM2 tyrosine phosphorylation
Signal regulatory protein α (SIRPα) plays an important part to restrain macrophage chemotaxis, secretion and phagocytosis. However, the signals involved in SIRPα-mediated control of macrophage inflammatory responses are poorly defined. Here we report that the inhibitory effect of SIRPα is mainly due to its suppression on macrophage aerobic glycolysis (Warburg effect).
Controlling macrophage phagocytosis towards healthy self cells: Two layers of activating and inhibitory mechanisms
Rapid clearance of adoptively transferred CD47-null cells in mice suggests a critical self-recognition mechanism, in which CD47 is the ubiquitous marker of ‘self’, and its interaction with macrophage SIRPα triggers inhibitory signaling through SIRPα cytoplasmic ITIMs and tyrosine phosphatase SHP-1/2.
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