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Abstract Osteoarthritis (OA) is a whole-joint disorder characterized by cartilage degeneration, synovial inflammation, subchondral bone remodeling, pain and progressive functional impairment. Current management remains largely symptomatic, and no widely accepted disease-modifying therapy is available. Extracellular vesicles (EVs) mediate intercellular communication by transferring regulatory RNAs, proteins, lipids, metabolites and other bioactive molecules.
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