SYSTEMATIC REVIEW article Volume 15 - 2025 | https://doi.org/10.3389/fonc.2025.1706837 This article is part of the Research TopicInnovative Strategies for the Discovery of New Therapeutic Targets in Cancer TreatmentView all 14 articles 1 Introduction The DNA damage response (DDR) is a signaling network that preserves genomic stability by repairing DNA lesions, regulating the cell cycle, and inducing apoptosis, thereby preventing mutagenesis and tumorigenesis (1, 2).
