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Zhijie Su

As seen in: Wiley Online Library, BioRxiv
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Articles by Zhijie Su

Adipocyte-Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

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By Jiarui Liu, Bingwei Wang, Zhijie Su
| Wiley Online Library Verified
1 Introduction Obesity, a chronic disease defined by excessive fat accumulation, has become an important cause of morbidity and mortality in humans [1]. Obesity results from the dysregulation of energy balance [2, 3]. Adipokines, proteins secreted by adipose tissue, play critical roles in the regulation of energy balance [4]. For instance, leptin activates hypothalamus to promote fat utilization, elevate energy expenditure (EE), reduce appetite and body weight [5-7].
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The DMHGABA Neurons Play a Crucial Role in The Regulation of Cold‐Induced White Adipose Browning through DMH to LPO Projection

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By Zhijie Su, Yujia Hou, Bingwei Wang, Qian Zhou
| Wiley Online Library Verified
1 Introduction The white adipose tissue (WAT) browning can convert lipidoverloaded WAT into energy-dissipating beige adipose tissue.[1, 2] WAT browning is characterized by reduced adipocyte volume, formation of multilocular lipid droplets in white adipocytes, enhanced fat utilization, elevated energy expenditure (EE), reduced whole-body adiposity, and lowered body weight.[1, 3, 4] It is estimated that in adult humans, the browned subcutaneous fat may account for nearly 15% of resting EE or...
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Identification of leptolin as a novel anti-obesity adipokine

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By Jiarui Liu, Bingwei Wang, Xiaoxu Han, Zhijie Su
| BioRxiv
Abstract Adipokines are key factors in regulating energy homeostasis. We identified a novel adipokine; we named it Leptolin. In humans, leptolin levels in white adipose tissue were positively corrected with exercise, and negatively associated with body mass index. Leptolin levels were positively correlated with lipolysis-promoting gene expression. Elevated leptolin in plasma of athletes, whereas lowered leptolin in plasma of obese individuals were observed.
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