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Abstract: Objective: To explore whether osteopeptide (GDT) exerts a protective effect on osteoporotic rats by reducing oxidative damage through the BMP/Smads/RUNX2 pathway. Methods: SD rats were randomly divided into normal control group, model group, alendronate group (1.33 mg/kg), and osteopeptide low, medium and high dose groups (50, 100, 200 mg/kg). After 2 weeks of retinoic acid modeling, the rats were continuously administered by gavage for 4 weeks.
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