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Supporting Information Filename Description JMS_5165-sup-0001-SM.docxWord 2007 document , 3.1 MB Figure S1. Photos of a) paper strip on nanoESI device and b) sampling area using paper strip. Table S1. Ingredient information of skin drugs. Table S2. Experimental data for the determination of precision (n = 6) of the PSMS detection of seven drugs in different concentrations. Table S3. Experimental data for LOD (S/N = 3) and LOQ (S/N = 10) of the PSMS detection of seven drugs. Table S4.
Rapid and sensitive detection of metabolites and chemical residues in human tears is highly beneficial for understanding eye health. In this study, Schirmer paper was used for noninvasive microsampling of human tears, and then paper spray mass spectrometry (PSMS) was performed for direct analysis of human tears. Schirmer PSMS was successfully used for rapid diagnosis of dry-eye syndrome by detecting the volume and metabolites of human tears.
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