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Zijun Cao

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Articles by Zijun Cao

USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis

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By Deqi Wang, Jianzhao Zhang, Yimin Lin, Yanqi Xu Verified, Lili Ma, Zijun Cao, Jiaqing Chen, Jun Xu, Wenhua Zheng, Jing Ruan, Xu Wang, Jiangyun Shen, Deyu Deng, Liyan Lou, Keshuo Jin, Fuqi Mei, Yangping Shentu
| Nature Verified
Abstract Nucleotide-binding oligomerization domain containing 2 (NOD2) recognizes conserved bacterial components in the cytoplasm to initiate innate immune responses, and its mutations are closely associated with Crohn’s disease (CD). Here, we discover that the NOD2 signaling is regulated by the deubiquitinase USP25. Macrophages lacking USP25 exhibit impaired NOD2 signaling and are defective in cytokine production upon stimulation with muramyl dipeptide (MDP).
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Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

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By Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Zhenhu Zhu
| Wiley Online Library Verified
1 Introduction Microglia actively participate in CNS development, homeostasis, and diseases.[1] Microglia sense tissue damage and microbial invasion by recognizing damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), respectively, through pattern recognition receptors (PRRs) and subsequently produce a plethora of inflammatory molecules, leading to the establishment of a neuroinflammatory milieu.[2] In particular, stimulation of the PRR Toll-like...
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A Real-Time Refined Roughness Estimation Framework for the Digital Twin Model Calibration of Irrigation Canal Systems

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By Xin Tian, Wangjiayi Liu, Guanghua Guan, Zijun Cao
| ascelibrary.org
Supplemental Materials File (supplemental_materials_jidedh.ireng-10227_liu.pdf) Data Availability Statement All data, models, or codes that support the findings of this study are available from the corresponding author upon reasonable request. Acknowledgments This work is funded by the National Natural Science Foundation of China (Grant nos.
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