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A close temporal association has been observed between the onset of some autoimmune connective tissue diseases (CTD) and various cancers, suggesting that the appearance of a CTD may sometimes represent a paraneoplastic phenomenon. For example, adult patients with dermatomyositis (DM) with anti-transcription intermediary factor 1 (anti-TIF1) autoantibodies have a dramatically increased risk of developing cancer compared to the general population [1].
AbstractObjective. We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis.Methods. There were 381 patients investigated for anti-HMGCR using ELISA.Results. Anti-HMGCR autoantibodies were detected in 4 patients (1%). These children had no or minimal rash and significant muscle disease.
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