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A. Aljabbari on Muck Rack

A. Aljabbari

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Articles

Effects of different mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance

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By Y. Y. Li, M. Figueiredo, T. Bethiana, A. Aljabbari, H. Mitra, M. Baghbanbashi, G. S. Harris, S. R. Dasaro, F. Masoomi, F. S. Vago, S. L. Hartzler, L. A. Metskas, P. Vlachos, A. M. Ardekani, Y. Yeo, K. Ristroph
| Nature Verified
Abstract Lipid nanoparticle (LNP) formulation requires a mixing step. Many studies, especially from academic groups, utilize microfluidic mixers or hand mixing to prepare LNPs, while commercial-scale processes use turbulent-flow mixers. This discrepancy in mixing techniques has been underexplored, as LNPs made by different techniques may exhibit different performance, meaning bench-scale results cannot be replicated using materials manufactured at scale.
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